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For Depression: "I had really severe depression for years and different anti-depressants weren't helping.

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Another case report described mirtazapine as inducing in a -treated patient, likely due to occupancy of α 2 autoreceptors by mirtazapine limiting the efficacy of concurrent clonidine therapy.

However, a single study regarding the combination reported it does not result in any incidence of serotonin-related toxicity.

For example, gastric obstruction needs to be carefully ruled out and acute gastroenteritis needs to be treated using antibiotics.

The trial may also be prematurely discontinued due to lack of recruitment or upon advice from the TSC, which will advise on whether to continue or discontinue the trial and make a recommendation to the sponsor.

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Has anyone stopped taking it and reverted back to their normal weight?

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This risk must be balanced with the clinical need.

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The intervention is simple, and is likely to be taken-up in primary care if found to be effective and not associated with an unacceptable level of adverse effects such as weight gain in longer-term use.

Most medications seem to list it but it's not really a common effect with most of them.

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Mirtazapine Tablets may cause serious side effects, including all of those described in the section entitled “What is the most important information I should know about Mirtazapine Tablets?

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Selective serotonin reuptake inhibitors (SSRIs) have replaced tricyclic antidepressants as the drugs of choice in the treatment of depressive disorders, mainly because of their improved tolerability and safety if taken in overdose.

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These agents are varyingly effective, but may result in daytime sleepiness, cognitive impairment, and anticholinergic effects that persist into the day after use, affecting driving performance.

SSRIs are a second line treatment of adult (OCD) with mild functional impairment and as first line treatment for those with moderate or severe impairment.

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Based on these limited data, it is unknown whether or not the dose of Mirtazapine Orally Disintegrating Tablets needed for maintenance treatment is identical to the dose needed to achieve an initial response.

Mirtazapine did not cause relevant changes in the pharmacokinetics of cimetidine.

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Comparison between single-agent mirtazapine ingestions and mirtazapine with co-ingestants showed that the co-ingested drug is often more important and this latter group had more serious outcomes ().

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Serotonin toxicity only occurred in patients ingesting known serotonergic drugs, sertraline and citalopram, and did not occur in single-agent mirtazapine overdoses.

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